Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 6/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 6/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.37 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.37 |
| ▸ | SIK1 | P57059 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.37 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30760263 | 0.80 | CHEK1 (0.45) | — | |
| SCHEMBL30180095 | 0.76 | FEN1 (0.49) | IKBKETBK1FEN1KDM4EALDH1A1 | |
| SCHEMBL30760475 | 0.71 | JAK1 (0.39) | KIT | |
| SCHEMBL23535650 | 0.70 | L3MBTL1 (0.50) | IKBKETBK1PRKAB2ABL1CSF1R | |
| SCHEMBL23559705 | 0.70 | IKBKE (0.50) | IKBKETBK1FEN1PRKAB2ABL1 | |
| SCHEMBL23535709 | 0.70 | USP30 (0.59) | IKBKETBK1FEN1PRKAB2ABL1 | |
| SCHEMBL26146265 | 0.70 | PIK3CD (0.42) | KDM4EALDH1A1LMNAMAPTPKM | |
| SCHEMBL30760415 | 0.69 | FYN (0.39) | FGFR3KDR | |
| SCHEMBL2828291 | 0.69 | L3MBTL1 (0.68) | IKBKETBK1ALDH1A1 | |
| SCHEMBL15882108 | 0.69 | PRKAB2 (0.41) | PRKAB2PRKAG1PRKAA1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247595-A1 | PYRAZOLOPYRAZINE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |