SCHEMBL30765129

SCHEMBL30765129

NC(=O)c1ccc(OCc2ccccc2Cl)cc1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 2/20 0.75
MAOB P27338 4/20 0.73
MAOA P21397 1/20 0.73
PARP10 Q53GL7 8/20 0.68
PARP15 Q460N3 1/20 0.68
PARP14 Q460N5 1/20 0.68
RAB9A P51151 2/20 0.57
NPC1 O15118 1/20 0.57
MEN1 O00255 2/20 0.56
KMT2A Q03164 2/20 0.56
MAPT P10636 1/20 0.56
HTT P42858 1/20 0.56
RAD52 P43351 1/20 0.56
NPSR1 Q6W5P4 1/20 0.56
F2 P00734 1/20 0.55
PRSS1 P07477 1/20 0.55
PRSS2 P07478 1/20 0.55
PRSS3 P35030 1/20 0.55
TMPRSS6 Q8IU80 1/20 0.55
ST14 Q9Y5Y6 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2666376 0.86 NR4A2 (0.63) NR4A2MAOBMAOAPARP10PARP15
SCHEMBL2087098 0.84 MAOB (1.00) NR4A2MAOBMAOARAB9ANPC1
SCHEMBL4638863 0.84 NR4A2 (0.77) NR4A2MAOBMAOAPARP10PARP15
SCHEMBL7170719 0.83 NR4A2 (0.71) NR4A2MAOBMAOARAB9ANPC1
SCHEMBL10396449 0.82 MAOB (0.74) NR4A2MAOBMAOARAB9ANPC1
SCHEMBL20883219 0.81 PARP10 (1.00) MAOBPARP10PARP15PARP14RAB9A
SCHEMBL30765166 0.81 PARP10 (1.00) NR4A2MAOBPARP10PARP15PARP14
SCHEMBL3618405 0.80 MAPT (0.70) NR4A2MAOBMAOARAB9ANPC1
SCHEMBL30765116 0.80 PARP10 (0.59) NR4A2MAOBMAOAPARP10PARP15
SCHEMBL1008781 0.80 NR4A2 (0.72) NR4A2MAOBMAOARAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112424181-B Substituted condensed thiophenes as STING modulators 希泰克斯特私人有限公司 2024-02-27 CN disclosed