Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | GRK5 | P34947 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27260524 | 1.00 | SMN1; SMN2 (0.52) | SMN1; SMN2PTK2ERN1SMYD2FYN | |
| SCHEMBL725156 | 0.87 | FYN (0.49) | FYNKMT2A | |
| SCHEMBL723443 | 0.87 | FYN (0.58) | PTK2FYNMAP4K4KMT2A | |
| SCHEMBL723071 | 0.85 | FYN (0.54) | PTK2FYNMAP4K4GRK5 | |
| SCHEMBL722768 | 0.83 | FYN (0.49) | PTK2FYNMAP4K4GRK5PIM1 | |
| SCHEMBL724106 | 0.83 | PDE4C (0.44) | SMN1; SMN2PTK2FYN | |
| SCHEMBL15210436 | 0.82 | FYN (0.46) | SMN1; SMN2PTK2FYN | |
| SCHEMBL15210439 | 0.82 | FYN (0.46) | SMN1; SMN2PTK2FYN | |
| SCHEMBL15210437 | 0.82 | FYN (0.46) | SMN1; SMN2PTK2FYN | |
| SCHEMBL15210451 | 0.81 | FYN (0.43) | SMN1; SMN2PTK2FYNKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |