Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 3/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27263347 | 1.00 | NPC1 (0.43) | NPC1ALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL30765379 | 1.00 | NPC1 (0.43) | NPC1ALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL27263346 | 1.00 | NPC1 (0.43) | NPC1ALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL30765285 | 0.91 | GLRA1 (0.39) | NPC1NAMPT | |
| SCHEMBL30765202 | 0.91 | GLRA1 (0.39) | NPC1NAMPT | |
| SCHEMBL30765255 | 0.91 | GLRA1 (0.39) | NPC1NAMPT | |
| SCHEMBL32672625 | 0.88 | NPC1 (0.42) | NPC1ALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL32672563 | 0.88 | NPC1 (0.42) | NPC1ALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL32672657 | 0.88 | NPC1 (0.42) | NPC1ALDH1A1HPGDHSD17B10NPSR1 | |
| SCHEMBL27267083 | 0.88 | NPC1 (0.42) | NPC1ALDH1A1HPGDHSD17B10NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |