Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 5/20 | 0.54 |
| ▸ | TYK2 | P29597 | 5/20 | 0.54 |
| ▸ | JAK2 | O60674 | 4/20 | 0.54 |
| ▸ | JAK3 | P52333 | 4/20 | 0.54 |
| ▸ | ERN1 | O75460 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL723230 | 1.00 | JAK1 (0.54) | JAK1TYK2JAK2JAK3ERN1 | |
| SCHEMBL724240 | 0.91 | PIK3CD (0.49) | JAK1TYK2JAK2JAK3ERN1 | |
| SCHEMBL725175 | 0.86 | ACVR1 (0.42) | JAK1TYK2JAK2JAK3HPGD | |
| SCHEMBL722851 | 0.84 | PDE4C (0.46) | JAK1TYK2JAK2JAK3ERN1 | |
| SCHEMBL27261867 | 0.84 | HPGD (0.48) | JAK1TYK2JAK2JAK3ERN1 | |
| SCHEMBL30765276 | 0.84 | HPGD (0.48) | JAK1TYK2JAK2JAK3ERN1 | |
| SCHEMBL724085 | 0.84 | PDE4C (0.45) | JAK1TYK2JAK2JAK3ERN1 | |
| SCHEMBL27920235 | 0.83 | JAK1 (0.40) | JAK1TYK2JAK2JAK3HPGD | |
| SCHEMBL724106 | 0.82 | PDE4C (0.44) | JAK1TYK2JAK2JAK3L3MBTL1 | |
| SCHEMBL27261388 | 0.82 | HPGD (0.46) | JAK1TYK2JAK2JAK3ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024033280-A1 | FUROPYRIDIN AND FUROPYRIMIDIN, INHIBITORS OF PI4K, FOR USE IN THE TREATMENT OF PARASITE INFECTION AND MALARIA | MERCK PATENT GMBH (DE) | 2024-02-15 | — | — | WO | disclosed |