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SCHEMBL30765754

SCHEMBL30765754

CC(C)(C)[Si](C)(C)OC[C@@H](Nc1ncc(N2CCCCC2)n(CC(=O)NCc2cc3cnccc3[nH]2)c1=O)c1ccc2oc3ccccc3c2c1

nearest known ligand 0.34

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 1/20 0.34
▸ NAMPT P43490 2/20 0.31
▸ F2 P00734 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30765645 0.90 MAPK1 (0.35) MAPK1NAMPTF2
SCHEMBL30765626 0.84 USP2 (0.33) MAPK1
SCHEMBL30765656 0.84 KMT2A (0.34) MAPK1
SCHEMBL30765728 0.83 MAPK1 (0.38) MAPK1NAMPTF2
SCHEMBL30765646 0.78 MAPK1 (0.38) MAPK1NAMPTF2
SCHEMBL30765440 0.76 F7 (0.39) MAPK1F2
SCHEMBL30765753 0.74 F2 (0.34) MAPK1F2
SCHEMBL30765686 0.74 F2 (0.35) MAPK1NAMPTF2
SCHEMBL30765806 0.73 MAPK1 (0.36) MAPK1NAMPTF2
SCHEMBL30765871 0.73 F2 (0.36) MAPK1NAMPTF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4568666-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS Alexion Pharmaceuticals, Inc. (US) 2025-06-18 — — EP disclosed
WO-2024035686-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2024-02-15 — — WO disclosed