SCHEMBL30765764

SCHEMBL30765764

O=C(Cn1c(-c2ccc(F)cc2)ncc(NCc2ccc3oc4ccccc4c3c2)c1=O)NCc1cc2cnccc2[nH]1

nearest known ligand 0.40

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
CMA1 P23946 16/20 0.40
CTRC Q99895 2/20 0.39
CES2 O00748 1/20 0.39
CTSG P08311 1/20 0.37
NAMPT P43490 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30765846 0.96 CMA1 (0.38) CMA1CTRCCES2CTSG
SCHEMBL30765494 0.91 F3 (0.34) CMA1CTRC
SCHEMBL30765579 0.90 F3 (0.39) CMA1CTRC
SCHEMBL30765987 0.90 F2 (0.37) CMA1CTRCNAMPT
SCHEMBL30765604 0.89 AVPR1B (0.34) CMA1NAMPT
SCHEMBL30765845 0.88 TDP1 (0.36) CMA1
SCHEMBL30765535 0.84 F2 (0.34) NAMPT
SCHEMBL30765643 0.84 NAMPT (0.35) NAMPT
SCHEMBL31558399 0.84 CMA1 (0.36) CMA1CTRCCTSGNAMPT
SCHEMBL30765877 0.83 CMA1 (0.37) CMA1CTRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4568666-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS Alexion Pharmaceuticals, Inc. (US) 2025-06-18 EP disclosed
CN-119768164-A Pharmaceutical compounds for treating complement-mediated disorders 阿雷克森制药公司 2025-04-04 CN disclosed
WO-2024035686-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2024-02-15 WO disclosed