SCHEMBL30765604

SCHEMBL30765604

O=C(Cn1c(-c2ccc(OC3COC3)cc2)ncc(NCc2ccc3oc4ccccc4c3c2)c1=O)NCc1cc2cnccc2[nH]1

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
AVPR1B P47901 10/20 0.34
CASP1 P29466 1/20 0.34
KDR P35968 1/20 0.33
CMA1 P23946 4/20 0.33
NAMPT P43490 2/20 0.32
F2 P00734 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30765764 0.89 CMA1 (0.40) CMA1NAMPT
SCHEMBL30765846 0.89 CMA1 (0.38) AVPR1BCMA1
SCHEMBL30765987 0.87 F2 (0.37) CASP1KDRCMA1NAMPTF2
SCHEMBL30765494 0.86 F3 (0.34) CASP1KDRCMA1F2
SCHEMBL30765579 0.86 F3 (0.39) CASP1CMA1F2
SCHEMBL31558414 0.85 KDR (0.33) KDRCMA1NAMPT
SCHEMBL30765845 0.85 TDP1 (0.36) CASP1CMA1F2
SCHEMBL30765470 0.84 AVPR1B (0.37) AVPR1BCASP1CMA1F2
SCHEMBL30765716 0.84 F2 (0.37) AVPR1BCASP1CMA1F2
SCHEMBL30765805 0.84 LMNA (0.39) AVPR1BCASP1CMA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4568666-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS Alexion Pharmaceuticals, Inc. (US) 2025-06-18 EP disclosed
CN-119768164-A Pharmaceutical compounds for treating complement-mediated disorders 阿雷克森制药公司 2025-04-04 CN disclosed
WO-2024035686-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2024-02-15 WO disclosed