Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 7/20 | 0.41 |
| ▸ | GYS1 | P13807 | 1/20 | 0.40 |
| ▸ | EBP | Q15125 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30768627 | 0.98 | ESR1 (0.42) | GRIN1GRIN2BESR1GYS1EBP | |
| SCHEMBL30769116 | 0.96 | EBP (0.40) | GRIN1GRIN2BESR1GYS1EBP | |
| SCHEMBL30769426 | 0.89 | ADRA1D (0.44) | GRIN1GRIN2BESR1EBPSIGMAR1 | |
| SCHEMBL29632097 | 0.88 | EBP (0.49) | GRIN1GRIN2BESR1EBPSIGMAR1 | |
| SCHEMBL20211928 | 0.88 | EBP (0.49) | GRIN1GRIN2BESR1EBPSIGMAR1 | |
| SCHEMBL30768653 | 0.87 | ESR1 (0.46) | GRIN1GRIN2BESR1EBPSIGMAR1 | |
| SCHEMBL30769280 | 0.86 | HRH3 (0.45) | GRIN1GRIN2BESR1EBPSIGMAR1 | |
| SCHEMBL30768962 | 0.86 | ESR1 (0.52) | GRIN1GRIN2BESR1EBPSIGMAR1 | |
| SCHEMBL30769002 | 0.85 | ESR1 (0.46) | GRIN1GRIN2BESR1EBPSIGMAR1 | |
| SCHEMBL30340457 | 0.85 | EBP (0.44) | GRIN1GRIN2BESR1EBPSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543871-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | Relay Therapeutics, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2024006781-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |