Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 18/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 14/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30768577 | 1.00 | ESR1 (0.39) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL30769262 | 1.00 | ESR1 (0.39) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL27083141 | 0.91 | ESR1 (0.39) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL30768821 | 0.88 | ESR1 (0.41) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL30769167 | 0.88 | ESR1 (0.41) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL29966494 | 0.87 | ESR1 (0.43) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL27081586 | 0.87 | ESR1 (0.43) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL30773568 | 0.86 | ESR1 (0.40) | ESR1ESR2CRBNDRD2DRD3 | |
| SCHEMBL29966734 | 0.86 | ESR1 (0.44) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL29966401 | 0.86 | ESR1 (0.44) | ESR1ESR2CRBNMLNRNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543871-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | Relay Therapeutics, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2024006781-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |