Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | MLNR | O43193 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29966401 | 1.00 | ESR1 (0.44) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL30768821 | 0.90 | ESR1 (0.41) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL30769167 | 0.90 | ESR1 (0.41) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL30773568 | 0.88 | ESR1 (0.40) | ESR1ESR2CRBNDRD2DRD3 | |
| SCHEMBL31541204 | 0.88 | ESR1 (0.46) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL31541263 | 0.88 | ESR1 (0.46) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL27083141 | 0.87 | ESR1 (0.39) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL27081586 | 0.87 | ESR1 (0.43) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL29966494 | 0.87 | ESR1 (0.43) | ESR1ESR2CRBNMLNRNR1I2 | |
| SCHEMBL30768580 | 0.86 | ESR1 (0.39) | ESR1ESR2CRBNMLNRNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116917280-B | Tetrahydronaphthalene compound, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2026-05-12 | — | — | CN | disclosed |
| US-20260098027-A1 | PHARMACEUTICALLY ACCEPTABLE SALT AND CRYSTAL FORM OF TETRAHYDRONAPHTHALENE DERIVATIVE, AND PREPARATION METHOD | JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN) | 2026-04-09 | — | — | US | disclosed |
| EP-4596538-A1 | PHARMACEUTICALLY ACCEPTABLE SALT AND CRYSTAL FORM OF TETRAHYDRONAPHTHALENE DERIVATIVE, AND PREPARATION METHOD | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2025-08-06 | — | — | EP | disclosed |
| CN-120035586-A | Pharmaceutically acceptable salts and crystal forms of tetrahydronaphthalene derivatives and preparation method thereof | 江苏恒瑞医药股份有限公司 | 2025-05-23 | — | — | CN | disclosed |
| US-20250099596-A1 | TETRAHYDRONAPHTHALENE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2025-03-27 | — | — | US | disclosed |
| EP-4317146-A1 | TETRAHYDRONAPHTHALENE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2024-02-07 | — | — | EP | disclosed |
| CN-116917280-A | Tetrahydronaphthalene compound, preparation method thereof and application thereof in medicine | 江苏恒瑞医药股份有限公司 | 2023-10-20 | — | — | CN | disclosed |
| WO-2022206737-A1 | TETRAHYDRONAPHTHALENE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | 江苏恒瑞医药股份有限公司 | 2022-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260098027-A1 | PHARMACEUTICALLY ACCEPTABLE SALT AND CRYSTAL FORM OF TETRAHYDRONAPHTHALENE DERIVATIVE, AND PREPARATION METHOD | MDH2, MDH1, GOT1 | ESR1 4671/4885ESR2 4648/4885CRBN 4349/4885 |
| US-20250099596-A1 | TETRAHYDRONAPHTHALENE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | CYP51A1, CYP46A1, HSD17B11 | ESR1 17/4885ESR2 33/4885CRBN 1103/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.