Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 4/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.51 |
| ▸ | USP2 | O75604 | 7/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | KHK | P50053 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.39 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30769340 | 1.00 | DDB1 (0.51) | DDB1CRBNCYP2D6ALDH1A1CYP3A4 | |
| SCHEMBL30723747 | 0.92 | CRBN (0.54) | DDB1CRBNCYP2D6ALDH1A1CYP3A4 | |
| SCHEMBL31306915 | 0.87 | CRBN (0.56) | DDB1CRBNCYP2D6ALDH1A1CYP3A4 | |
| SCHEMBL23267981 | 0.82 | CRBN (0.54) | DDB1CRBNALDH1A1CYP3A4USP2 | |
| SCHEMBL1426558 | 0.78 | CYP2D6 (0.61) | CYP2D6ALDH1A1CYP3A4USP2CYP1A2 | |
| SCHEMBL30769297 | 0.77 | ALDH1A1 (0.49) | DDB1CRBNCYP2D6ALDH1A1CYP3A4 | |
| SCHEMBL20455740 | 0.76 | CYP2D6 (0.60) | CYP2D6ALDH1A1CYP3A4USP2CYP1A2 | |
| SCHEMBL20842185 | 0.76 | CYP2D6 (0.60) | CYP2D6ALDH1A1CYP3A4USP2CYP1A2 | |
| SCHEMBL30769043 | 0.76 | DDB1 (0.48) | DDB1CRBNCYP2D6ALDH1A1CYP3A4 | |
| SCHEMBL1426810 | 0.76 | CYP2D6 (0.82) | CYP2D6ALDH1A1CYP3A4USP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250388565-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. | 2025-12-25 | — | — | US | disclosed |
| EP-4543871-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | Relay Therapeutics, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2024006781-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250388565-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND METHODS OF USE THEREOF | ESRRA, ESRRB, ESR2 | DDB1 2204/4885CRBN 488/4885CYP2D6 361/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.