Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 19/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30768792 | 1.00 | ESR1 (0.45) | ESR1ESR2CRBN | |
| SCHEMBL30769026 | 0.86 | ESR1 (0.47) | ESR1ESR2CRBN | |
| SCHEMBL30769315 | 0.86 | ESR1 (0.47) | ESR1ESR2CRBN | |
| SCHEMBL30769087 | 0.86 | ESR1 (0.43) | ESR1ESR2CRBN | |
| SCHEMBL30769301 | 0.86 | ESR1 (0.43) | ESR1ESR2CRBN | |
| SCHEMBL31541207 | 0.86 | ESR1 (0.48) | ESR1ESR2 | |
| SCHEMBL29966734 | 0.86 | ESR1 (0.44) | ESR1ESR2CRBN | |
| SCHEMBL29966401 | 0.86 | ESR1 (0.44) | ESR1ESR2CRBN | |
| SCHEMBL31571949 | 0.84 | ESR1 (0.54) | ESR1ESR2CRBN | |
| SCHEMBL20234598 | 0.84 | ESR1 (0.54) | ESR1ESR2CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543871-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | Relay Therapeutics, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| EP-4317146-A1 | TETRAHYDRONAPHTHALENE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2024-02-07 | — | — | EP | disclosed |
| WO-2024006781-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |