Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 13/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | WDR91 | A4D1P6 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22013513 | 1.00 | NLRP3 (0.43) | NLRP3ATMSMN1; SMN2ALDH1A1PARP1 | |
| SCHEMBL30243890 | 1.00 | NLRP3 (0.43) | NLRP3ATMSMN1; SMN2ALDH1A1PARP1 | |
| SCHEMBL22012763 | 0.92 | NLRP3 (0.43) | NLRP3ATMSMN1; SMN2ALDH1A1PARP1 | |
| SCHEMBL30244308 | 0.92 | NLRP3 (0.43) | NLRP3ATMSMN1; SMN2ALDH1A1PARP1 | |
| SCHEMBL30770628 | 0.92 | NLRP3 (0.43) | NLRP3ATMSMN1; SMN2ALDH1A1PARP1 | |
| SCHEMBL30243962 | 0.92 | NLRP3 (0.43) | NLRP3ATMSMN1; SMN2ALDH1A1PARP1 | |
| SCHEMBL22012257 | 0.83 | NLRP3 (0.34) | NLRP3ATMSMN1; SMN2ALDH1A1PARP1 | |
| SCHEMBL25795439 | 0.81 | NLRP3 (0.57) | NLRP3 | |
| SCHEMBL22012628 | 0.80 | NLRP3 (0.43) | NLRP3 | |
| SCHEMBL30243936 | 0.80 | NLRP3 (0.43) | NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880659-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2024-01-03 | — | — | EP | disclosed |