Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1768162 | 0.84 | SMN1; SMN2 (0.61) | SMN1; SMN2KMT2AGAAPOLBKDM4E | |
| SCHEMBL19695450 | 0.84 | MAPK1 (0.47) | SMN1; SMN2KMT2AGAAPOLBKDM4E | |
| SCHEMBL16447604 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2KMT2AGAAPOLBKDM4E | |
| SCHEMBL12294564 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2KMT2AGAAKDM4EMAPT | |
| SCHEMBL21893931 | 0.79 | MAPT (0.45) | SMN1; SMN2KMT2AGAAPOLBKDM4E | |
| SCHEMBL25327960 | 0.78 | ALDH1A1 (0.41) | SMN1; SMN2KMT2AGAAKDM4EMAPT | |
| SCHEMBL974116 | 0.76 | KDM4E (0.40) | SMN1; SMN2GAAPOLBKDM4EMAPT | |
| SCHEMBL954716 | 0.76 | EPHB3 (0.57) | SMN1; SMN2KMT2AGAAPOLBKDM4E | |
| SCHEMBL19697349 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2KMT2AGAAKDM4EMAPT | |
| SCHEMBL954146 | 0.76 | KMT2A (0.76) | SMN1; SMN2KMT2AGAAPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117769546-A | Allosteric ketene inhibitors of phosphoinositide 3-kinase (PI 3K) for the treatment of disease | 佩特拉制药公司 | 2024-03-26 | — | — | CN | disclosed |