Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | TLR4 | O00206 | 1/20 | 0.40 |
| ▸ | TLR3 | O15455 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | QDPR | P09417 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terikalant SCHEMBL1815992 | 1.00 | KCNH2 (1.00) | KCNH2DRD2NPSR1SLC6A4TLR9 | |
| Terikalant SCHEMBL9678648 | 1.00 | KCNH2 (1.00) | KCNH2DRD2NPSR1SLC6A4TLR9 | |
| Terikalant SCHEMBL9772825 | 0.99 | KCNH2 (0.98) | KCNH2DRD2NPSR1SLC6A4TLR9 | |
| SCHEMBL18509377 | 0.94 | KCNH2 (0.89) | KCNH2DRD2ABCB1 | |
| SCHEMBL9014359 | 0.94 | KCNH2 (0.89) | KCNH2DRD2NPSR1TLR9TLR7 | |
| Terikalant SCHEMBL10407782 | 0.92 | KCNH2 (0.84) | KCNH2DRD2ACHEHTR2A | |
| Terikalant SCHEMBL1230246 | 0.92 | KCNH2 (0.84) | KCNH2DRD2ACHEHTR2A | |
| Terikalant SCHEMBL1230245 | 0.92 | KCNH2 (0.84) | KCNH2DRD2ACHEHTR2A | |
| Terikalant SCHEMBL10407783 | 0.92 | KCNH2 (0.84) | KCNH2DRD2ACHEHTR2A | |
| SCHEMBL10407769 | 0.91 | KCNH2 (0.84) | KCNH2DRD2QDPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024091485-A1 | COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING PULMONARY FIBROSIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-05-02 | — | — | WO | disclosed |
| EP-3355925-B1 | TREATMENT OF ACUTE TRAUMATIC INJURY | UNIV ROCHESTER (US) | 2024-02-28 | — | — | EP | disclosed |