Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.89 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terikalant SCHEMBL9678648 | 0.94 | KCNH2 (1.00) | KCNH2DRD2NPSR1TLR9TLR7 | |
| Terikalant SCHEMBL1815992 | 0.94 | KCNH2 (1.00) | KCNH2DRD2NPSR1TLR9TLR7 | |
| Terikalant SCHEMBL30770792 | 0.94 | KCNH2 (1.00) | KCNH2DRD2NPSR1TLR9TLR7 | |
| Terikalant SCHEMBL9772825 | 0.93 | KCNH2 (0.98) | KCNH2DRD2NPSR1TLR9TLR7 | |
| SCHEMBL9014406 | 0.89 | KCNH2 (0.83) | KCNH2DRD2NPSR1TLR9TLR7 | |
| SCHEMBL9014779 | 0.89 | KCNH2 (0.70) | KCNH2DRD2SIGMAR1 | |
| SCHEMBL18509377 | 0.88 | KCNH2 (0.89) | KCNH2DRD2SIGMAR1 | |
| SCHEMBL9014758 | 0.88 | KCNH2 (0.69) | KCNH2DRD2SIGMAR1TLR9TLR7 | |
| SCHEMBL9014729 | 0.88 | KCNH2 (0.69) | KCNH2DRD2SIGMAR1TLR9TLR7 | |
| SCHEMBL9014400 | 0.88 | KCNH2 (0.69) | KCNH2DRD2TLR9TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | claimed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | claimed |
| US-5495022-A | Piperidines and piperazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1996-02-27 | — | — | US | disclosed |
| EP-0634398-A1 | 4-Phenylpiperidinyl-1/-piperazinyl-1-ethylsubstituted benzofusedheterocycles as antiarrhythmic agents | MERCK PATENT GmbH (DE) | 1995-01-18 | — | — | EP | disclosed |