Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.43 |
| ▸ | PLK1 | P53350 | 4/20 | 0.42 |
| ▸ | MET | P08581 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27040032 | 0.94 | ALK (0.49) | EGFRALKPLK1METCDC7 | |
| SCHEMBL30776682 | 0.94 | ALK (0.49) | EGFRALKPLK1METCDC7 | |
| SCHEMBL30776714 | 0.90 | EGFR (0.53) | EGFRALKPLK1METLRRK2 | |
| SCHEMBL30958178 | 0.88 | EGFR (0.44) | EGFRALKPLK1METCDC7 | |
| SCHEMBL30776702 | 0.85 | EGFR (0.53) | EGFRALKPLK1METLRRK2 | |
| SCHEMBL27039977 | 0.85 | EGFR (0.53) | EGFRALKPLK1METLRRK2 | |
| SCHEMBL30776698 | 0.85 | PLK1 (0.47) | EGFRALKPLK1METULK1 | |
| SCHEMBL30776710 | 0.83 | EGFR (0.52) | EGFRALKPLK1LRRK2 | |
| SCHEMBL31005794 | 0.82 | EGFR (0.52) | EGFRALKPLK1METULK1 | |
| SCHEMBL27040037 | 0.82 | LRRK2 (0.50) | EGFRALKPLK1METCDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024017251-A1 | MACROCYCLE FOR INHIBITING AND INDUCING EGFR DEGRADATION AND PREPARATION METHOD FOR AND USE OF MACROCYCLE | 江苏恒瑞医药股份有限公司 | 2024-01-25 | — | — | WO | disclosed |