Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 6/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27039977 | 1.00 | EGFR (0.53) | EGFRMETPLK1LRRK2ALK | |
| SCHEMBL30776714 | 0.95 | EGFR (0.53) | EGFRMETPLK1LRRK2ALK | |
| SCHEMBL31005793 | 0.90 | EGFR (0.52) | EGFRMETPLK1ALK | |
| SCHEMBL30776682 | 0.90 | ALK (0.49) | EGFRMETPLK1ALK | |
| SCHEMBL27040032 | 0.90 | ALK (0.49) | EGFRMETPLK1ALK | |
| SCHEMBL30958182 | 0.89 | EGFR (0.50) | EGFRMETPLK1LRRK2ALK | |
| SCHEMBL30776710 | 0.88 | EGFR (0.52) | EGFRPLK1LRRK2ALK | |
| SCHEMBL31005792 | 0.88 | EGFR (0.54) | EGFRPLK1LRRK2ALK | |
| SCHEMBL27040037 | 0.88 | LRRK2 (0.50) | EGFRMETPLK1LRRK2ALK | |
| SCHEMBL30937109 | 0.86 | EGFR (0.54) | EGFRMETPLK1LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024017251-A1 | MACROCYCLE FOR INHIBITING AND INDUCING EGFR DEGRADATION AND PREPARATION METHOD FOR AND USE OF MACROCYCLE | 江苏恒瑞医药股份有限公司 | 2024-01-25 | — | — | WO | disclosed |