Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 8/20 | 0.40 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | TYK2 | P29597 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 2/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23910159 | 1.00 | JAK1 (0.40) | JAK1JAK2TYK2JAK3OPRM1 | |
| SCHEMBL21724877 | 0.84 | JAK1 (0.50) | JAK1JAK2TYK2JAK3OPRM1 | |
| SCHEMBL21724451 | 0.79 | TLR7 (0.42) | JAK1JAK2TYK2JAK3OPRM1 | |
| SCHEMBL23037671 | 0.75 | NQO2 (0.39) | NQO2GFERALDH1A1DYRK1AEGFR | |
| SCHEMBL21724405 | 0.73 | JAK2 (0.30) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL23037651 | 0.71 | NQO2 (0.40) | NQO2GFERALDH1A1 | |
| SCHEMBL21724518 | 0.70 | JAK1 (0.53) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL23037626 | 0.69 | GRM2 (0.35) | NQO2DYRK1AEGFRRAF1KDR | |
| SCHEMBL23037516 | 0.69 | PDPK1 (0.40) | NQO2DYRK1AEGFRRAF1KDR | |
| SCHEMBL20475939 | 0.68 | NLRP3 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3837015-B1 | IMIDAZO[4,5-C]QUINOLINE DERIVED NLRP3-MODULATORS | INNATE TUMOR IMMUNITY INC (US) | 2024-02-14 | — | — | EP | disclosed |