Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | FDPS | P14324 | 3/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916434 | 0.79 | HDAC1 (0.43) | ALDH1A1FDPSHDAC3HDAC4HDAC1 | |
| SCHEMBL8918704 | 0.79 | HDAC1 (0.43) | ALDH1A1FDPSHDAC3HDAC4HDAC1 | |
| SCHEMBL8915912 | 0.77 | HDAC1 (0.41) | ALDH1A1FDPSHDAC3HDAC4HDAC1 | |
| SCHEMBL8915921 | 0.77 | HDAC1 (0.41) | ALDH1A1FDPSHDAC3HDAC4HDAC1 | |
| SCHEMBL8918712 | 0.77 | HDAC1 (0.41) | ALDH1A1FDPSHDAC3HDAC4HDAC1 | |
| SCHEMBL8918707 | 0.77 | HDAC1 (0.41) | ALDH1A1FDPSHDAC3HDAC4HDAC1 | |
| SCHEMBL420011 | 0.77 | ALDH1A1 (0.78) | ALDH1A1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL23051126 | 0.76 | ALDH1A1 (0.56) | ALDH1A1FDPSHDAC3HDAC4HDAC1 | |
| SCHEMBL22773976 | 0.75 | KCNA3 (0.59) | ALDH1A1FDPSHDAC3HDAC4HDAC1 | |
| SCHEMBL28947840 | 0.75 | ALDH1A1 (0.50) | ALDH1A1HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250188055-A1 | Acyl Sulfonamides that are BCL Family Antagonists for Use in Clinical Management of Conditions Caused or Mediated by Senescent Cells and for Treating Cancer | UNITY BIOTECHNOLOGY, INC. | 2025-06-12 | — | — | US | disclosed |
| US-12221433-B2 | Acyl sulfonamides that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer | UNITY BIOTECHNOLOGY, INC. (US) | 2025-02-11 | — | — | US | disclosed |
| EP-4335516-A2 | ACYL SULFONAMIDES THAT ARE BCL FAMILY ANTAGONISTS FOR USE IN CLINICAL MANAGEMENT OF CONDITIONS CAUSED OR MEDIATED BY SENESCENT CELLS AND FOR TREATING CANCER | Unity Biotechnology, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12221433-B2 | Acyl sulfonamides that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer | BCL2, MCL1, BAD | ALDH1A1 2512/4885FDPS 1703/4885HDAC3 105/4885 |
| US-20250188055-A1 | Acyl Sulfonamides that are BCL Family Antagonists for Use in Clinical Management of Conditions Caused or Mediated by Senescent Cells and for Treating Cancer | BCL2, MCL1, BAD | ALDH1A1 2512/4885FDPS 1703/4885HDAC3 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.