Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | FSHR | P23945 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27138078 | 0.84 | GSK3B (0.45) | GSK3BDYRK1AATRBRD4MAPKAPK2 | |
| SCHEMBL27152501 | 0.83 | ABL1 (0.35) | GSK3BDYRK1AABL1 | |
| SCHEMBL30780156 | 0.76 | GSK3B (0.36) | GSK3BDYRK1ABRD4TLR9TLR8 | |
| SCHEMBL10288086 | 0.73 | GSK3B (0.54) | GSK3BDYRK1AATRMAPKAPK2CDK9 | |
| SCHEMBL18308988 | 0.70 | GSK3B (0.47) | GSK3BDYRK1AATRMAPKAPK2RORC | |
| SCHEMBL21287636 | 0.70 | BRD4 (0.35) | GSK3BDYRK1AATRBRD4IRAK4 | |
| SCHEMBL20520009 | 0.69 | GSK3B (0.47) | GSK3BDYRK1AATRMAPKAPK2RORC | |
| SCHEMBL14151806 | 0.69 | GSK3B (0.55) | GSK3BDYRK1AMAPKAPK2CDK9IRAK4 | |
| SCHEMBL30636341 | 0.68 | GSK3B (0.60) | GSK3BDYRK1AMAPK1ABL1 | |
| SCHEMBL28166698 | 0.68 | GSK3B (0.60) | GSK3BDYRK1AMAPK1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4577546-A1 | NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES | Enliven Inc. (US) | 2025-07-02 | — | — | EP | disclosed |
| WO-2024044713-A1 | NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES | ENLIVEN INC. (US) | 2024-02-29 | — | — | WO | disclosed |