Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | MB | P02144 | 1/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | RARG | P13631 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855498 | 0.83 | POLB (0.63) | POLBPKMSMN1; SMN2MEN1MAPT | |
| SCHEMBL4983137 | 0.79 | POLB (0.51) | POLBPKMSMN1; SMN2MEN1MAPT | |
| SCHEMBL21438694 | 0.79 | POLB (0.51) | POLBPKMSMN1; SMN2MEN1MAPT | |
| SCHEMBL6402141 | 0.79 | POLB (0.58) | POLBPKMSMN1; SMN2MEN1MAPT | |
| SCHEMBL1092347 | 0.78 | PKM (0.51) | POLBPKMMEN1MAPTKMT2A | |
| SCHEMBL29939067 | 0.77 | POLB (0.53) | POLBPKMSMN1; SMN2MEN1MAPT | |
| SCHEMBL9582949 | 0.77 | POLB (0.53) | POLBPKMSMN1; SMN2MEN1MAPT | |
| SCHEMBL27389402 | 0.77 | PKM (0.61) | POLBPKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8590962 | 0.76 | TYR (0.56) | POLBPKMSMN1; SMN2MEN1MAPT | |
| SCHEMBL28627643 | 0.75 | EGFR (0.57) | POLBPKMSMN1; SMN2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024030651-A1 | GPX4 INHIBITORS AND USE THEREOF | SONATA THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |