Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | TTR | P02766 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.53 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215804 | 1.00 | TDP1 (0.58) | TDP1TTRALDH1A1HPGDLMNA | |
| SCHEMBL357288 | 0.87 | HTT (0.60) | TDP1TTRALDH1A1HPGDLMNA | |
| SCHEMBL8964829 | 0.86 | TDP1 (0.62) | TDP1ALDH1A1HPGDLMNAHTT | |
| SCHEMBL8973475 | 0.86 | TDP1 (0.62) | TDP1ALDH1A1HPGDLMNAHTT | |
| SCHEMBL16959290 | 0.84 | NPBWR1 (0.56) | TDP1TTRALDH1A1HPGDLMNA | |
| SCHEMBL4652150 | 0.83 | TDP1 (0.58) | TDP1ALDH1A1HPGDLMNAHTT | |
| SCHEMBL3749821 | 0.83 | TDP1 (0.58) | TDP1ALDH1A1HPGDLMNAHTT | |
| SCHEMBL3749823 | 0.83 | TDP1 (0.58) | TDP1ALDH1A1HPGDLMNAHTT | |
| SCHEMBL18216619 | 0.83 | TDP1 (0.58) | TDP1ALDH1A1HPGDLMNAHTT | |
| SCHEMBL922726 | 0.83 | TDP1 (0.58) | TDP1ALDH1A1HPGDLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024030651-A1 | GPX4 INHIBITORS AND USE THEREOF | SONATA THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |