SCHEMBL30786125

SCHEMBL30786125

COC(=O)c1ccc(SCc2ccc(OC)cc2)cc1F

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.53
MAOA P21397 2/20 0.50
APP P05067 1/20 0.49
HDAC3 O15379 1/20 0.48
NCOR1 O75376 1/20 0.48
HDAC1 Q13547 1/20 0.48
HDAC2 Q92769 1/20 0.48
DAO P14920 1/20 0.47
CYP1A2 P05177 2/20 0.45
KDM4E B2RXH2 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
TP53 P04637 1/20 0.43
ALDH1A1 P00352 2/20 0.42
LMNA P02545 1/20 0.42
HPGD P15428 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
GAA P10253 1/20 0.42
BCL2L11 O43521 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30786206 0.90 MAOB (0.52) MAOBMAOAAPPHDAC3NCOR1
SCHEMBL23166638 0.82 MAOB (0.48) MAOBMAOAAPPHDAC3NCOR1
SCHEMBL30786181 0.80 MAPT (0.46) DAOCYP1A2KDM4ECYP2D6CYP2C9
SCHEMBL17080153 0.80 MAPT (0.46) DAOCYP1A2KDM4ECYP2D6CYP2C9
SCHEMBL17080124 0.79 KDM4E (0.52) APPDAOCYP1A2KDM4ECYP2D6
SCHEMBL14893940 0.77 MAOB (0.63) MAOBMAOAALDH1A1FFAR1
SCHEMBL7095625 0.77 HDAC3 (0.49) MAOBMAOAAPPHDAC3NCOR1
SCHEMBL1554929 0.77 CPS1 (0.61) CYP1A2KDM4ECYP2D6CYP2C9CYP2C19
SCHEMBL17080240 0.77 KDM4E (0.46) HDAC3NCOR1HDAC1HDAC2CYP1A2
SCHEMBL30786136 0.77 KDM4E (0.46) HDAC3NCOR1HDAC1HDAC2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025082316-A1 OPHTHALMIC FORMATION, AND PREPARATION METHOD THEREFOR AND USE THEREOF 苏州必扬医药科技有限公司 2025-04-24 WO disclosed
WO-2024032584-A1 PROTEIN TYROSINE KINASE INHIBITOR AND MEDICAL USE THEREOF 苏州必扬医药科技有限公司 2024-02-15 WO disclosed