Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | PAK4 | O96013 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | CSF1R | P07333 | 2/20 | 0.32 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.32 |
| ▸ | KIT | P10721 | 2/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30786084 | 0.88 | KDR (0.44) | KDRPOLBTP53LMNAFGFR1 | |
| SCHEMBL30786173 | 0.85 | KDR (0.44) | KDRPOLBFGFR1PLK4AURKA | |
| SCHEMBL31475200 | 0.85 | KDR (0.46) | KDRPOLBTP53LMNAFGFR1 | |
| SCHEMBL30786229 | 0.85 | KDR (0.44) | KDRPOLBFGFR1PLK4AURKA | |
| SCHEMBL30786069 | 0.82 | KDR (0.62) | KDRFGFR1PLK4AURKAMAP4K4 | |
| SCHEMBL31475183 | 0.80 | KDR (0.46) | KDRPOLBTP53LMNATHRB | |
| SCHEMBL31475317 | 0.80 | KDR (0.47) | KDRPOLBTP53LMNATHRB | |
| SCHEMBL30786112 | 0.79 | KDR (0.44) | KDRPOLBLMNATHRBFGFR1 | |
| SCHEMBL31475189 | 0.79 | KDR (0.46) | KDRPOLBLMNATHRBFGFR1 | |
| SCHEMBL31475226 | 0.78 | KDR (0.64) | KDRFGFR1PLK4AURKAMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024032584-A1 | PROTEIN TYROSINE KINASE INHIBITOR AND MEDICAL USE THEREOF | 苏州必扬医药科技有限公司 | 2024-02-15 | — | — | WO | disclosed |