Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.65 |
| ▸ | JAK3 | P52333 | 13/20 | 0.64 |
| ▸ | JAK1 | P23458 | 8/20 | 0.64 |
| ▸ | TYK2 | P29597 | 4/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.64 |
| ▸ | PLK4 | O00444 | 2/20 | 0.64 |
| ▸ | CIT | O14578 | 2/20 | 0.64 |
| ▸ | GAK | O14976 | 2/20 | 0.64 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.64 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.64 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.64 |
| ▸ | MARK3 | P27448 | 2/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.64 |
| ▸ | NEK3 | P51956 | 2/20 | 0.64 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.64 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.64 |
| ▸ | ULK3 | Q6PHR2 | 2/20 | 0.64 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 2/20 | 0.64 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.64 |
| ▸ | ADCK1 | Q86TW2 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30788210 | 1.00 | JAK2 (0.65) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL27388539 | 0.87 | JAK2 (0.68) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL30788201 | 0.85 | JAK2 (0.65) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL30788209 | 0.85 | JAK2 (0.65) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL27387208 | 0.85 | JAK2 (0.65) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL27387206 | 0.85 | JAK2 (0.65) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL34463177 | 0.84 | JAK2 (0.68) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL27387029 | 0.82 | JAK2 (0.76) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL2865873 | 0.80 | JAK2 (0.82) | JAK2JAK3JAK1TYK2HDAC1 | |
| Hydrochloric Acid SCHEMBL30221695 | 0.79 | JAK2 (0.96) | JAK2JAK3JAK1TYK2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024035771-A2 | ULK3 INHIBITORS AND USES THEREOF | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2024-02-15 | — | — | WO | disclosed |