Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.65 |
| ▸ | JAK3 | P52333 | 13/20 | 0.64 |
| ▸ | JAK1 | P23458 | 5/20 | 0.64 |
| ▸ | TYK2 | P29597 | 4/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.64 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.59 |
| ▸ | FLT3 | P36888 | 2/20 | 0.59 |
| ▸ | PLK4 | O00444 | 2/20 | 0.59 |
| ▸ | CIT | O14578 | 2/20 | 0.59 |
| ▸ | GAK | O14976 | 2/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.59 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.59 |
| ▸ | MARK3 | P27448 | 2/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30788209 | 1.00 | JAK2 (0.65) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL27387206 | 1.00 | JAK2 (0.65) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL27387208 | 1.00 | JAK2 (0.65) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL27387226 | 0.91 | JAK2 (0.62) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL27388539 | 0.87 | JAK2 (0.68) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL30788188 | 0.85 | JAK2 (0.65) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL30788210 | 0.85 | JAK2 (0.65) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL27387029 | 0.82 | JAK2 (0.76) | JAK2JAK3JAK1TYK2HDAC1 | |
| SCHEMBL30788197 | 0.82 | KIT (0.55) | JAK2JAK3HDAC1HDAC6FLT3 | |
| SCHEMBL30788203 | 0.82 | KIT (0.55) | JAK2JAK3HDAC1HDAC6FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260103455-A1 | ULK3 INHIBITORS AND USES THEREOF | H LEE MOFFITT CANCER CT & RES (US) | 2026-04-16 | — | — | US | disclosed |
| WO-2024035771-A2 | ULK3 INHIBITORS AND USES THEREOF | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2024-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260103455-A1 | ULK3 INHIBITORS AND USES THEREOF | ULK3, ULK1, ULK2 | JAK2 2451/4885JAK3 819/4885JAK1 1428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.