Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6289489 | 0.76 | TAAR1 (0.44) | TP53RAB9ASMN1; SMN2KDM4EEPHX1 | |
| SCHEMBL918756 | 0.73 | NOTUM (0.47) | RAB9ASMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL11448976 | 0.72 | TP53 (0.74) | TP53RAB9AMEN1KMT2APOLB | |
| Acetanilide SCHEMBL5706383 | 0.72 | NAPRT (0.59) | TP53RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL19749 | 0.71 | ELANE (0.47) | TP53RAB9ASMN1; SMN2KDM4EEPHX1 | |
| Biphenyl SCHEMBL2202263 | 0.70 | NOTUM (0.44) | TP53RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL2885210 | 0.69 | NPC1 (0.81) | TP53RAB9ASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL1502065 | 0.69 | KMT2A (0.50) | TP53SMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL4502875 | 0.68 | — | — | |
| SCHEMBL11030408 | 0.68 | SMN1; SMN2 (0.42) | TP53RAB9ASMN1; SMN2KDM4EEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523663-A1 | PHARMACEUTICAL USE OF MULTICYCLIC COMPOUNDS AS ANTI-AIDS AGENTS | Amazonia Fitomedicamentos Ltda (BR) | 2012-11-21 | — | — | EP | disclosed |
| US-7790160-B2 | Method of treating CD30 positive lymphomas | MEDAREX, INC. (US) | 2010-09-07 | — | — | US | disclosed |
| CN-101056655-A | Methods of treating CD30 positive lymphomas | MEDAREX INC (US) | 2007-10-17 | — | — | CN | disclosed |
| EP-1802345-A2 | METHODS OF TREATING CD30 POSITIVE LYMPHOMAS | Medarex, Inc. (US) | 2007-07-04 | — | — | EP | disclosed |
| US-20060177442-A1 | Method of treating CD30 positive lymphomas | MEDAREX, INC. (US) | 2006-08-10 | — | — | US | disclosed |
| WO-2006039644-A2 | METHODS OF TREATING CD30 POSITIVE LYMPHOMAS | MEDAREX, INC. (US) | 2006-04-13 | — | — | WO | disclosed |