Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 4/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | KAT7 | O95251 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.34 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.34 |
| ▸ | PARG | Q86W56 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20605746 | 1.00 | MCL1 (0.41) | MCL1GPR119KAT7KAT6AEGLN2 | |
| SCHEMBL20604810 | 0.90 | MCL1 (0.49) | MCL1PTGER4 | |
| SCHEMBL20604962 | 0.90 | MCL1 (0.43) | MCL1PTGER4 | |
| SCHEMBL30790922 | 0.90 | MCL1 (0.49) | MCL1PTGER4 | |
| SCHEMBL20605018 | 0.84 | MCL1 (0.44) | MCL1PTGER4 | |
| SCHEMBL20604942 | 0.80 | MCL1 (0.46) | MCL1CDK9 | |
| SCHEMBL20604830 | 0.78 | DYRK1A (0.35) | MCL1 | |
| SCHEMBL20604886 | 0.74 | DRD2 (0.38) | MCL1 | |
| SCHEMBL20604991 | 0.73 | MCL1 (0.45) | MCL1SYKPTGER4 | |
| SCHEMBL20604843 | 0.71 | MCL1 (0.42) | MCL1SYKPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4292662-A2 | SUBSTITUTED INDOLE MCL-1 INHIBITORS | Vanderbilt University (US) | 2023-12-20 | — | — | EP | disclosed |