Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 2/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | CTSG | P08311 | 1/20 | 0.47 |
| ▸ | PREP | P48147 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30793887 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ACYP2C19HTR2C | |
| SCHEMBL30793442 | 1.00 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9ACYP2C19HTR2C | |
| SCHEMBL22778699 | 0.89 | AGTR2 (0.50) | SMN1; SMN2NPC1RAB9ACYP2C19HTR2C | |
| SCHEMBL2282075 | 0.81 | HTR2C (0.52) | SMN1; SMN2NPC1RAB9ACYP2C19HTR2C | |
| SCHEMBL30793726 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9ACYP2C19HTR2C | |
| SCHEMBL22958177 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9ACYP2C19HTR2C | |
| SCHEMBL30793590 | 0.81 | SMN1; SMN2 (0.48) | SMN1; SMN2NPC1RAB9ACYP2C19HTR2C | |
| SCHEMBL30251765 | 0.80 | SMN1; SMN2 (0.58) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 | |
| SCHEMBL20587819 | 0.79 | HTR2C (0.54) | SMN1; SMN2NPC1RAB9ACYP2C19HTR2C | |
| SCHEMBL30793193 | 0.79 | PREP (0.49) | SMN1; SMN2NPC1RAB9ACYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4540254-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| WO-2023244604-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-12-21 | — | — | WO | disclosed |