Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.56 |
| ▸ | NAMPT | P43490 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 5/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | CYBB | P04839 | 1/20 | 0.38 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.38 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.38 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1018783 | 0.92 | NR1H2 (0.58) | NR1H2NAMPTESR2MAPK1MAPT | |
| SCHEMBL6890800 | 0.85 | NR1H2 (0.62) | NR1H2NAMPTESR2MAPK1MAPT | |
| SCHEMBL8223979 | 0.84 | NR1H2 (0.55) | NR1H2NAMPTESR2MAPK1MAPT | |
| SCHEMBL31535874 | 0.83 | NR1H2 (0.53) | NR1H2NAMPTESR2MAPK1MAPT | |
| SCHEMBL30508929 | 0.79 | NAMPT (0.44) | NR1H2NAMPTESR2MAPK1MAPT | |
| SCHEMBL31549281 | 0.79 | NR1H2 (0.55) | NR1H2NAMPTESR2MAPK1MAPT | |
| SCHEMBL6111584 | 0.77 | SPR (0.45) | NR1H2NAMPTMAPK1MAPTPSEN1 | |
| Pyrazole SCHEMBL4014508 | 0.77 | NR1H2 (0.56) | NR1H2NAMPTESR2MAPK1MAPT | |
| SCHEMBL25337422 | 0.76 | ESR2 (0.40) | NR1H2ESR2MAPK1MAPTHPGD | |
| SCHEMBL16968266 | 0.76 | NR1H2 (0.41) | NR1H2NAMPTACACBPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4540254-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| CN-119454705-A | Formulations and methods of use of RBP4 inhibitors | 倍亮生物有限责任公司 | 2025-02-18 | — | — | CN | disclosed |
| WO-2023244604-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-12-21 | — | — | WO | disclosed |