Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | CYBB | P04839 | 1/20 | 0.35 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.35 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.35 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30793502 | 0.88 | GPR119 (0.38) | MEN1KMT2AGPR119PDE4APDE4B | |
| SCHEMBL30793120 | 0.87 | GPR119 (0.37) | MEN1KMT2AGPR119PDE4APDE4B | |
| SCHEMBL30793124 | 0.87 | MEN1 (0.40) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL30793957 | 0.85 | MEN1 (0.37) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL25337280 | 0.84 | NR1H2 (0.42) | MEN1KMT2ACYBBNOX5NOX4 | |
| SCHEMBL26686738 | 0.84 | MEN1 (0.43) | MEN1KMT2AGPR119CYBBNOX5 | |
| SCHEMBL25335687 | 0.84 | MEN1 (0.43) | MEN1KMT2ACYBBNOX5NOX4 | |
| SCHEMBL26687047 | 0.84 | ADORA1 (0.42) | MEN1KMT2AGPR119CYBBNOX5 | |
| SCHEMBL24535149 | 0.81 | MEN1 (0.40) | MEN1KMT2AGPR119CYBBNOX5 | |
| SCHEMBL26686561 | 0.81 | HPGD (0.41) | MEN1KMT2ACYBBNOX5NOX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4540254-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| WO-2023244604-A1 | TETRAHYDROPYRIDOPYRIMIDINE PAN-KRAS INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-12-21 | — | — | WO | disclosed |