SCHEMBL30795652

SCHEMBL30795652

Cc1cc(NCc2ccc(C(F)(F)F)cc2)cc(N2CCOCC2)c1NC(=O)CC(C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GAA P10253 5/20 0.46
SRPK1 Q96SB4 1/20 0.45
ALDH1A1 P00352 5/20 0.45
KCNQ2 O43526 3/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
KCNQ3 O43525 1/20 0.45
LMNA P02545 3/20 0.43
MAPT P10636 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
KDM4E B2RXH2 3/20 0.43
HPGD P15428 1/20 0.43
MCHR1 Q99705 1/20 0.42
TSHR P16473 1/20 0.42
LDHA P00338 1/20 0.42
LDHB P07195 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3094833 1.00 GAA (0.46) GAASRPK1ALDH1A1KCNQ2SMN1; SMN2
SCHEMBL31576842 0.77 KCNQ2 (0.58) SRPK1ALDH1A1KCNQ2SMN1; SMN2KCNQ3
SCHEMBL22288452 0.76 KCNQ3 (0.59) KCNQ2KCNQ3LMNAHPGD
SCHEMBL22288483 0.76 KCNQ2 (0.57) SRPK1ALDH1A1KCNQ2SMN1; SMN2KCNQ3
SCHEMBL3101145 0.75 KCNQ2 (0.50) KCNQ2KCNQ3MAPTL3MBTL1
SCHEMBL30795469 0.75 KCNQ2 (0.50) KCNQ2KCNQ3MAPTL3MBTL1
SCHEMBL14271378 0.73 MAPT (0.56) ALDH1A1KCNQ2SMN1; SMN2LMNAMAPT
SCHEMBL22299365 0.72 KCNQ3 (0.62) GAAKCNQ2KCNQ3LMNAMAPT
SCHEMBL3596698 0.72 PPARA (0.55) ALDH1A1KCNQ2KCNQ3KDM4E
SCHEMBL2070060 0.72 POLB (0.57) GAAALDH1A1LMNAL3MBTL1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4584250-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS Biohaven Therapeutics Ltd. (VG) 2025-07-16 EP disclosed
EP-4580679-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND NMDA RECEPTOR ANTAGONISTS Biohaven Therapeutics Ltd. (VG) 2025-07-09 EP disclosed
WO-2024054811-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS BIOHAVEN THERAPEUTICS LTD. (VG) 2024-03-14 WO disclosed
WO-2024054807-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND TDP-43 MODULATORS BIOHAVEN THERAPEUTICS LTD. (VG) 2024-03-14 WO disclosed
WO-2024050389-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND NMDA RECEPTOR ANTAGONISTS BIOHAVEN THERAPEUTICS LTD. (VG) 2024-03-07 WO disclosed