SCHEMBL30795772

SCHEMBL30795772

CC(C)(C)c1nn(NC(=O)CC(C)(C)c2ccccc2)c(=O)c2ccccc12

nearest known ligand 0.40

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
POLB P06746 3/20 0.40
ALDH1A1 P00352 3/20 0.39
RAB9A P51151 1/20 0.38
KMT2A Q03164 2/20 0.38
SMN1; SMN2 Q16637 1/20 0.36
HTT P42858 2/20 0.35
OPRK1 P41145 1/20 0.35
ALOX15 P16050 1/20 0.34
PKM P14618 1/20 0.34
MAPT P10636 1/20 0.34
TSHR P16473 1/20 0.34
MEN1 O00255 1/20 0.34
MAPK1 P28482 1/20 0.34
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1784808 1.00 POLB (0.40) POLBALDH1A1RAB9AKMT2ASMN1; SMN2
SCHEMBL1787049 0.92 MEN1 (0.40) POLBALDH1A1RAB9AKMT2ASMN1; SMN2
SCHEMBL30796204 0.92 MEN1 (0.40) POLBALDH1A1RAB9AKMT2ASMN1; SMN2
SCHEMBL1786996 0.85 MEN1 (0.48) POLBRAB9AKMT2ASMN1; SMN2ALOX15
SCHEMBL30795813 0.85 MEN1 (0.48) POLBRAB9AKMT2ASMN1; SMN2ALOX15
SCHEMBL30795922 0.85 KMT2A (0.40) POLBALDH1A1RAB9AKMT2AMAPT
SCHEMBL1788618 0.85 KMT2A (0.40) POLBALDH1A1RAB9AKMT2AMAPT
SCHEMBL1786762 0.83 TSHR (0.50) POLBALDH1A1RAB9AKMT2ASMN1; SMN2
SCHEMBL30795814 0.83 TSHR (0.50) POLBALDH1A1RAB9AKMT2ASMN1; SMN2
SCHEMBL13720970 0.82 ALDH1A1 (0.40) POLBALDH1A1RAB9ASMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4584250-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS Biohaven Therapeutics Ltd. (VG) 2025-07-16 EP disclosed
EP-4580679-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND NMDA RECEPTOR ANTAGONISTS Biohaven Therapeutics Ltd. (VG) 2025-07-09 EP disclosed
WO-2024054811-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS BIOHAVEN THERAPEUTICS LTD. (VG) 2024-03-14 WO disclosed
WO-2024054807-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND TDP-43 MODULATORS BIOHAVEN THERAPEUTICS LTD. (VG) 2024-03-14 WO disclosed
WO-2024050389-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS AND NMDA RECEPTOR ANTAGONISTS BIOHAVEN THERAPEUTICS LTD. (VG) 2024-03-07 WO disclosed