Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TK1 | P04183 | 2/20 | 0.38 |
| ▸ | TYMS | P04818 | 2/20 | 0.37 |
| ▸ | RNASE1 | P07998 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8424549 | 0.90 | TOP2A (0.52) | TOP2ATK1RNASE1 | |
| SCHEMBL3078239 | 0.86 | ALDH1A1 (0.42) | ALDH1A1POLBKMT2ASMN1; SMN2TK1 | |
| SCHEMBL6831233 | 0.81 | TOP2A (0.53) | TOP2ATK1RNASE1 | |
| SCHEMBL3066260 | 0.81 | SMN1; SMN2 (0.44) | ALDH1A1POLBKMT2ASMN1; SMN2TK1 | |
| SCHEMBL3072159 | 0.80 | SMN1; SMN2 (0.44) | ALDH1A1POLBKMT2ASMN1; SMN2TK1 | |
| SCHEMBL3066252 | 0.80 | SMN1; SMN2 (0.44) | ALDH1A1POLBKMT2ASMN1; SMN2TK1 | |
| SCHEMBL1172397 | 0.80 | TYMS (0.54) | SMN1; SMN2TK1TYMS | |
| SCHEMBL3087405 | 0.80 | ALDH1A1 (0.37) | TOP2AALDH1A1POLBKMT2ASMN1; SMN2 | |
| SCHEMBL24059082 | 0.80 | TOP2A (0.55) | TOP2ATK1RNASE1 | |
| SCHEMBL6830250 | 0.80 | TOP2A (0.51) | TOP2ATK1RNASE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054406-B1 | NUCLEOSIDES FOR SUPPRESSING OR REDUCING THE DEVELOPMENT OF RESISTANCE IN CYTOSTATIC THERAPY | RESPROTECT GMBH (DE) | 2015-10-07 | — | — | EP | disclosed |
| US-8492537-B2 | Nucleosides for suppressing or reducing the development of resistance in cytostatic therapy | RESPROTECT GMBH (DE) | 2013-07-23 | — | — | US | disclosed |
| US-20100227834-A1 | NUCLEOSIDES FOR SUPPRESSING OR REDUCING THE DEVELOPMENT OF RESISTANCE IN CYTOSTATIC THERAPY | RESprotech GmbH (DE) | 2010-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227834-A1 | NUCLEOSIDES FOR SUPPRESSING OR REDUCING THE DEVELOPMENT OF RESISTANCE IN CYTOSTATIC THERAPY | TYMP, ENTPD5, NTPCR | TOP2A 189/4885ALDH1A1 1238/4885POLB 288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.