Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 11/20 | 0.72 |
| ▸ | SMARCA4 | P51532 | 11/20 | 0.72 |
| ▸ | PBRM1 | Q86U86 | 9/20 | 0.72 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27461170 | 1.00 | SMARCA2 (0.72) | SMARCA2SMARCA4PBRM1PDK2NR1I2 | |
| SCHEMBL27461283 | 0.89 | SMARCA2 (0.57) | SMARCA2SMARCA4PBRM1PDK2PIK3CA | |
| SCHEMBL30796360 | 0.88 | SMARCA2 (0.58) | SMARCA2SMARCA4PBRM1PDK2PIK3CA | |
| SCHEMBL30796928 | 0.86 | SMARCA2 (0.54) | SMARCA2SMARCA4PBRM1PDK2PIK3CA | |
| SCHEMBL30796853 | 0.86 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1PDK2PIK3CA | |
| SCHEMBL27461169 | 0.86 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1PDK2PIK3CA | |
| SCHEMBL25347040 | 0.86 | SMARCA2 (0.76) | SMARCA2SMARCA4PBRM1PDK2NR1I2 | |
| SCHEMBL30520252 | 0.86 | SMARCA2 (0.76) | SMARCA2SMARCA4PBRM1PDK2NR1I2 | |
| SCHEMBL30667399 | 0.84 | PBRM1 (1.00) | SMARCA2SMARCA4PBRM1NR1I2BRD4 | |
| SCHEMBL18038763 | 0.84 | PBRM1 (1.00) | SMARCA2SMARCA4PBRM1NR1I2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4539849-A1 | COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 | C4 Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| WO-2023244764-A1 | COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 | C4 THERAPEUTICS, INC. (US) | 2023-12-21 | — | — | WO | disclosed |