Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.52 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.52 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.52 |
| ▸ | SUV39H2 | Q9H5I1 | 7/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27461169 | 1.00 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1SUV39H2MAP4K4 | |
| SCHEMBL27461346 | 0.87 | SMARCA2 (0.42) | SMARCA2SMARCA4PBRM1SUV39H2MAP4K4 | |
| SCHEMBL30796781 | 0.87 | SMARCA2 (0.42) | SMARCA2SMARCA4PBRM1SUV39H2MAP4K4 | |
| SCHEMBL30796629 | 0.86 | SMARCA2 (0.72) | SMARCA2SMARCA4PBRM1MAP4K4PDK2 | |
| SCHEMBL27461170 | 0.86 | SMARCA2 (0.72) | SMARCA2SMARCA4PBRM1MAP4K4PDK2 | |
| SCHEMBL25347440 | 0.84 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1MAP4K4MAPT | |
| SCHEMBL30520162 | 0.84 | SMARCA2 (0.53) | SMARCA2SMARCA4PBRM1MAP4K4MAPT | |
| SCHEMBL27461283 | 0.82 | SMARCA2 (0.57) | SMARCA2SMARCA4PBRM1MAP4K4MAPT | |
| SCHEMBL1432796 | 0.81 | POLB (0.53) | SUV39H2POLBMAPTPDK2MEN1 | |
| SCHEMBL30796928 | 0.80 | SMARCA2 (0.54) | SMARCA2SMARCA4PBRM1PDK2PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4539849-A1 | COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 | C4 Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| WO-2023244764-A1 | COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 | C4 THERAPEUTICS, INC. (US) | 2023-12-21 | — | — | WO | disclosed |