Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 5/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 5/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 7/20 | 0.37 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.37 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.34 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30797146 | 0.86 | TRPC3 (0.43) | SMARCA2SMARCA4TRPC3TRPC7SMN1; SMN2 | |
| SCHEMBL30796877 | 0.82 | SMARCA2 (0.47) | SMARCA2SMARCA4PBRM1 | |
| SCHEMBL29943535 | 0.79 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1 | |
| SCHEMBL30797042 | 0.77 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1HDAC1 | |
| SCHEMBL30797014 | 0.77 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1HDAC1 | |
| SCHEMBL30796207 | 0.76 | SMARCA2 (0.51) | SMARCA2SMARCA4PBRM1SMN1; SMN2 | |
| SCHEMBL27458085 | 0.75 | SMARCA2 (0.48) | SMARCA2SMARCA4PBRM1 | |
| SCHEMBL23301217 | 0.75 | PBRM1 (0.52) | SMARCA2SMARCA4PBRM1SMN1; SMN2CYP2C19 | |
| SCHEMBL30796712 | 0.74 | SMARCA2 (0.59) | SMARCA2SMARCA4PBRM1 | |
| SCHEMBL27458561 | 0.74 | SMARCA2 (0.59) | SMARCA2SMARCA4PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4539849-A1 | COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 | C4 Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| WO-2023244764-A1 | COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 | C4 THERAPEUTICS, INC. (US) | 2023-12-21 | — | — | WO | disclosed |