Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.43 |
| ▸ | CCND1 | P24385 | 3/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | CCND3 | P30281 | 3/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MAT2A | P31153 | 2/20 | 0.33 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | QPCT | Q16769 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291398 | 0.81 | SLC6A2 (0.42) | ELANECHRNB2CHRNA4CDK4CCNA2 | |
| SCHEMBL30797061 | 0.81 | CDK4 (0.41) | CDK4CCNA2CCND1CCNE1CDK2 | |
| SCHEMBL30797189 | 0.80 | PSEN1 (0.41) | CDK4CCNA2CCND1CCNE1CDK2 | |
| SCHEMBL8305787 | 0.78 | GAA (0.46) | ELANECDK4CCNA2CCND1CCNE1 | |
| SCHEMBL27250765 | 0.75 | HRH3 (0.47) | ELANECHRNB2CHRNA4CCNA2CDK2 | |
| SCHEMBL16701852 | 0.73 | DDB1 (0.39) | CDK4CCNA2CCND1CCNE1CDK2 | |
| SCHEMBL2234874 | 0.73 | GAA (0.44) | — | |
| SCHEMBL30797099 | 0.72 | NPC1 (0.45) | CDK4CCNA2CCND1CCNE1CDK2 | |
| SCHEMBL17689121 | 0.72 | HDAC6 (0.40) | ELANECHRNB2CHRNA4PDE4BDRD3 | |
| SCHEMBL26779877 | 0.71 | L3MBTL1 (0.49) | CDK4CCNA2CCND1CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023244817-A1 | SUBSTITUTED PIPERIDINES AS CK1A DEGRADERS | MONTE ROSA THERAPEUTICS, INC. (US) | 2023-12-21 | — | — | WO | disclosed |