Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF1 | Q13422 | 3/20 | 0.48 |
| ▸ | IKZF2 | Q9UKS7 | 3/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 17/20 | 0.48 |
| ▸ | IKZF3 | Q9UKT9 | 7/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | IL1B | P01584 | 1/20 | 0.47 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24718246 | 1.00 | IKZF1 (0.48) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL31023219 | 0.83 | CRBN (0.42) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL24718690 | 0.83 | CRBN (0.42) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL29927677 | 0.81 | CRBN (0.55) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL20234882 | 0.81 | CRBN (0.55) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL29338566 | 0.80 | CRBN (0.56) | IKZF2CRBNIKZF3DDB1CSNK1A1 | |
| SCHEMBL26093542 | 0.79 | CRBN (0.53) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL31033954 | 0.78 | CRBN (0.54) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL31033834 | 0.77 | CRBN (0.53) | IKZF1IKZF2CRBNIKZF3DDB1 | |
| SCHEMBL31736546 | 0.77 | CRBN (0.55) | IKZF1IKZF2CRBNIKZF3DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118388454-A | Modulators of BCL6 proteolysis and related methods of use | 阿尔维纳斯运营股份有限公司 | 2024-07-26 | — | — | CN | disclosed |
| EP-4323352-A1 | MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-02-21 | — | — | EP | disclosed |