Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27383531 | 0.82 | MAPT (0.61) | EGLN1LMNAMAPTMEN1KMT2A | |
| SCHEMBL30799122 | 0.82 | CNR1 (0.51) | CNR1CNR2EGLN1LMNAMAPT | |
| SCHEMBL27383527 | 0.82 | CNR1 (0.51) | CNR1CNR2EGLN1LMNAMAPT | |
| SCHEMBL4986377 | 0.78 | CNR1 (0.63) | CNR1CNR2EGLN1LMNAMAPT | |
| SCHEMBL30799051 | 0.78 | CNR1 (0.51) | CNR1CNR2EGLN1LMNAMAPT | |
| SCHEMBL30799185 | 0.76 | POLB (0.50) | CNR1CNR2EGLN1L3MBTL1ALDH1A1 | |
| SCHEMBL27621455 | 0.76 | POLB (0.53) | EGLN1MAPTSMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL30799000 | 0.75 | MAPT (0.46) | CNR1CNR2EGLN1LMNAMAPT | |
| SCHEMBL19788437 | 0.75 | PDPK1 (0.68) | CNR1CNR2SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL1866365 | 0.70 | EGLN1 (0.69) | EGLN1LMNAMAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024050825-A1 | COMPOUNDS AS MLKL INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2024-03-14 | — | — | WO | disclosed |