Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27383780 | 0.84 | MAPT (0.68) | MAPTPOLBTP53RXFP1LMNA | |
| SCHEMBL28223471 | 0.83 | MAPT (0.62) | MAPTPOLBTP53RXFP1LMNA | |
| SCHEMBL30799111 | 0.82 | CNR1 (0.51) | MAPTPOLBTP53LMNATHRB | |
| SCHEMBL20995404 | 0.82 | EGLN1 (0.69) | MAPTPOLBTP53RXFP1LMNA | |
| SCHEMBL27383530 | 0.79 | MAPT (0.65) | MAPTPOLBTP53RXFP1LMNA | |
| SCHEMBL17477640 | 0.78 | MAPT (0.63) | MAPTPOLBTP53RXFP1LMNA | |
| SCHEMBL27383551 | 0.77 | MAPT (0.56) | MAPTPOLBTP53RXFP1LMNA | |
| SCHEMBL14611520 | 0.76 | MAPT (0.57) | MAPTPOLBTP53LMNAMEN1 | |
| SCHEMBL29092601 | 0.75 | BRD4 (0.74) | MAPTTP53RXFP1LMNAMEN1 | |
| SCHEMBL30647255 | 0.75 | BRD4 (0.74) | MAPTTP53RXFP1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024050825-A1 | COMPOUNDS AS MLKL INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2024-03-14 | — | — | WO | disclosed |