Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | LPO | P22079 | 3/20 | 0.50 |
| ▸ | CMA1 | P23946 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32665427 | 0.89 | MAPT (0.59) | MAPTTP53LMNALPOCMA1 | |
| SCHEMBL17392844 | 0.84 | MAPK14 (0.70) | MAPTTP53LMNAMAPK14LPO | |
| SCHEMBL30798921 | 0.81 | MAPT (0.47) | MAPTTP53MAPK14KMT2AADORA2A | |
| SCHEMBL32665079 | 0.78 | MAPT (0.52) | MAPTTP53LMNAMAPK14CMA1 | |
| SCHEMBL30799080 | 0.78 | EGLN1 (0.47) | MAPTTP53LMNAMAPK14SIGMAR1 | |
| SCHEMBL461145 | 0.78 | MAPT (0.59) | MAPTTP53LMNAMAPK14LPO | |
| SCHEMBL18860613 | 0.77 | MAPT (0.55) | MAPTTP53LMNALPOCMA1 | |
| SCHEMBL30799185 | 0.76 | POLB (0.50) | MAPK14SIGMAR1 | |
| SCHEMBL18860611 | 0.76 | CNR1 (0.41) | LMNAMAPK14ADORA2ASIGMAR1 | |
| SCHEMBL28817529 | 0.75 | MAPT (0.63) | MAPTTP53LMNALPOCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024050825-A1 | COMPOUNDS AS MLKL INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2024-03-14 | — | — | WO | disclosed |