Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | DBH | P09172 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27383532 | 0.82 | MAPT (0.65) | EGLN1MAPK14TP53MAPTPOLB | |
| SCHEMBL30798921 | 0.82 | MAPT (0.47) | MAPK14TP53MAPTPOLBKDM4E | |
| SCHEMBL30799185 | 0.80 | POLB (0.50) | EGLN1MAPK14POLBKDM4EALDH1A1 | |
| SCHEMBL18860611 | 0.79 | CNR1 (0.41) | EGLN1MAPK14POLBLMNASIGMAR1 | |
| SCHEMBL27383587 | 0.79 | MAPK14 (0.58) | MAPK14TP53KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL27383546 | 0.79 | MAPT (0.49) | EGLN1TP53MAPTPOLBALDH1A1 | |
| SCHEMBL30799299 | 0.78 | MAPT (0.52) | MAPK14TP53MAPTLMNASIGMAR1 | |
| SCHEMBL25852107 | 0.76 | EGLN1 (0.54) | EGLN1MAPK14TP53MAPTPOLB | |
| SCHEMBL32665431 | 0.76 | MAPK14 (0.44) | EGLN1MAPK14POLBLMNACNR1 | |
| SCHEMBL18860569 | 0.75 | EGLN1 (0.53) | EGLN1TP53MAPTPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024050825-A1 | COMPOUNDS AS MLKL INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2024-03-14 | — | — | WO | disclosed |