Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP7 | P09237 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29874577 | 1.00 | HTT (0.48) | HTTSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL13681760 | 0.85 | PARP1 (0.55) | HTTSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL2820733 | 0.85 | PARP1 (0.55) | HTTSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL20129643 | 0.85 | PARP1 (0.55) | HTTSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL23249881 | 0.85 | PARP1 (0.49) | HTTSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL32684605 | 0.85 | PARP1 (0.49) | HTTSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL2708839 | 0.84 | PARP1 (0.43) | HTTSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL3843422 | 0.83 | PARP1 (0.42) | HTTSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL21876995 | 0.82 | SMN1; SMN2 (0.52) | HTTSMN1; SMN2NPC1RAB9APARP1 | |
| SCHEMBL21458909 | 0.82 | SMN1; SMN2 (0.52) | HTTSMN1; SMN2NPC1RAB9APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260070929-A1 | METHODS AND COMPOSITIONS FOR MODULATING KRAS(G12D) | RANOK THERAPEUTICS HANGZHOU CO LTD (CN) | 2026-03-12 | — | — | US | disclosed |
| CN-120018863-A | Methods and compositions for modulating KRAS (G12D) | 珃诺生物医药科技(杭州)有限公司 | 2025-05-16 | — | — | CN | disclosed |
| WO-2024044334-A2 | METHODS AND COMPOSITIONS FOR MODULATING KRAS(G12D) | RANOK THERAPEUTICS (HANGZHOU) CO. LTD. (CN) | 2024-02-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260070929-A1 | METHODS AND COMPOSITIONS FOR MODULATING KRAS(G12D) | KRAS, HRAS, NRAS | HTT 356/4885SMN1; SMN2 3326/4885NPC1 1581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.