Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.42 |
| ▸ | NEK2 | P51955 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3544514 | 0.88 | LMNA (0.55) | LMNAKDM4EABL1HTTNEK2 | |
| SCHEMBL24671781 | 0.82 | KDM4E (0.41) | LMNAKDM4EABL1HRH3ADRA1A | |
| SCHEMBL594954 | 0.79 | LMNA (0.67) | LMNAKDM4EABL1HRH3KMT2A | |
| SCHEMBL18403894 | 0.79 | HRH3 (0.51) | HRH3KMT2AGRIN2DGRIN3BGRIN1 | |
| SCHEMBL30191321 | 0.77 | HRH3 (0.49) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3387350 | 0.77 | HRH3 (0.49) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL15651219 | 0.77 | MAP4K4 (0.49) | LMNAKDM4EHTTHRH3KMT2A | |
| SCHEMBL15651714 | 0.77 | LMNA (0.56) | LMNAKDM4EABL1HRH3KMT2A | |
| SCHEMBL10126760 | 0.77 | GRIN2D (0.46) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2145523 | 0.77 | HRH3 (0.48) | LMNAKDM4EABL1HRH3GRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693502-A | Compounds for inhibiting or degrading ITK, compositions comprising the same, methods of making the same, and methods of using the same | 纽力克斯治疗公司 | 2024-03-12 | — | — | CN | disclosed |