Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 3/20 | 0.69 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.64 |
| ▸ | FLT1 | P17948 | 7/20 | 0.64 |
| ▸ | KDR | P35968 | 3/20 | 0.61 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.61 |
| ▸ | AURKA | O14965 | 2/20 | 0.61 |
| ▸ | JAK2 | O60674 | 2/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.61 |
| ▸ | PAK4 | O96013 | 2/20 | 0.61 |
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | LCK | P06239 | 2/20 | 0.61 |
| ▸ | RET | P07949 | 2/20 | 0.61 |
| ▸ | PRKACA | P17612 | 2/20 | 0.61 |
| ▸ | FLT3 | P36888 | 2/20 | 0.61 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.61 |
| ▸ | CLK2 | P49760 | 2/20 | 0.61 |
| ▸ | GSK3A | P49840 | 2/20 | 0.61 |
| ▸ | GSK3B | P49841 | 2/20 | 0.61 |
| ▸ | CDK7 | P50613 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3542400 | 1.00 | ITK (0.69) | ITKCHEK1FGFR1FLT1KDR | |
| SCHEMBL4919171 | 0.90 | FGFR1 (0.64) | ITKCHEK1FGFR1FLT1KDR | |
| SCHEMBL3535642 | 0.90 | CHEK1 (0.80) | ITKCHEK1FGFR1FLT1KDR | |
| SCHEMBL1224535 | 0.88 | FLT3 (0.66) | ITKCHEK1FGFR1FLT1KDR | |
| SCHEMBL4911894 | 0.86 | ITK (0.63) | ITKCHEK1FGFR1FLT1KDR | |
| SCHEMBL13373636 | 0.84 | ITK (0.70) | ITKCHEK1FGFR1FLT1KDR | |
| SCHEMBL31172403 | 0.84 | CHEK1 (0.70) | CHEK1FGFR1FLT1KDRFLT3 | |
| SCHEMBL3257676 | 0.84 | MAPK8 (0.62) | CHEK1MAPK8CHEK2MAPK9MAPK10 | |
| SCHEMBL31172388 | 0.82 | CHEK1 (0.58) | ITKCHEK1FLT3CHEK2MAP2K4 | |
| SCHEMBL31172453 | 0.82 | MMP2 (0.62) | ITKCHEK1FGFR1FLT3CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693502-A | Compounds for inhibiting or degrading ITK, compositions comprising the same, methods of making the same, and methods of using the same | 纽力克斯治疗公司 | 2024-03-12 | — | — | CN | disclosed |