Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | KRAS | P01116 | 4/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30131075 | 1.00 | JAK1 (0.33) | JAK1JAK2TYK2JAK3KRAS | |
| SCHEMBL31129339 | 0.94 | KRAS (0.39) | KRASMAPK3MAPK1 | |
| SCHEMBL31129721 | 0.94 | KRAS (0.39) | KRASMAPK3MAPK1 | |
| SCHEMBL31129533 | 0.94 | KRAS (0.39) | KRASMAPK3MAPK1 | |
| SCHEMBL30131061 | 0.93 | JAK1 (0.33) | JAK1JAK2TYK2JAK3KRAS | |
| SCHEMBL30801453 | 0.93 | JAK1 (0.33) | JAK1JAK2TYK2JAK3KRAS | |
| SCHEMBL30864096 | 0.92 | KRAS (0.34) | JAK1JAK2TYK2JAK3KRAS | |
| SCHEMBL30782214 | 0.91 | JAK1 (0.35) | JAK1JAK2TYK2JAK3GPR119 | |
| SCHEMBL30779081 | 0.91 | JAK1 (0.35) | JAK1JAK2TYK2JAK3GPR119 | |
| SCHEMBL30864064 | 0.91 | KRAS (0.34) | JAK1JAK2TYK2JAK3KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117460737-A | Heteroaromatic compounds, method for the production and use thereof | 四川科伦博泰生物医药股份有限公司 | 2024-01-26 | — | — | CN | disclosed |