Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 18/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31323525 | 0.94 | KRAS (0.41) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL31129481 | 0.94 | KRAS (0.41) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL30131061 | 0.92 | JAK1 (0.33) | KRASMAPK3MAPK1JAK1JAK2 | |
| SCHEMBL30801453 | 0.92 | JAK1 (0.33) | KRASMAPK3MAPK1JAK1JAK2 | |
| SCHEMBL31677249 | 0.92 | KRAS (0.42) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL30966201 | 0.92 | KRAS (0.42) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL30864096 | 0.92 | KRAS (0.34) | KRASMAPK3MAPK1JAK1JAK2 | |
| SCHEMBL30864137 | 0.91 | KRAS (0.38) | KRAS | |
| SCHEMBL30864136 | 0.91 | KRAS (0.38) | KRAS | |
| SCHEMBL29914136 | 0.91 | KRAS (0.36) | KRASMAPK3MAPK1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117917416-A | KRAS G12D degradation agent and preparation method and application thereof | 上海领泰生物医药科技有限公司 | 2024-04-23 | — | — | CN | disclosed |